среда, 10 июня 2009 г.

Eden? Maybe. But Where’s the Apple Tree?

A new genetic survey of people in Africa, the largest of its kind, suggests, however, that the region in southwest Africa seems, on the present evidence, to be the origin of modern humans. The authors have also identified some 14 ancestral populations.

The new data goes far toward equalizing the genetic picture of the world, given that most genetic information has come from European and Asian populations. But because it comes from Africa, the continent on which the human lineage evolved, it also sheds light on the origins of human life.

The origin of a species is generally taken to be the place where its individuals show the greatest genetic diversity. For humans, when the new African data is combined with DNA information from the rest of the world, this spot lies on the coast of southwest Africa near the Kalahari Desert, the research team, led by Sarah A. Tishkoff of the University of Pennsylvania, said in this week’s issue of Science.



The area is a homeland of the Bushmen or San people, whose language is distinguished by its many click sounds.

But the San in the past might not have been restricted to where they are now, she said. The San are thought to have once occupied a much larger area, one that probably stretched from southern Africa up the east coast to as far as present-day Ethiopia.

Since the geneticists’ calculations refer to people, not geography, the San — and therefore the site of greatest human diversity — might have been located elsewhere in the past.

Christopher Ehret, an expert on African languages at the University of California, Los Angeles, and a member of Dr. Tishkoff’s team, has detected traces of words borrowed from click languages in East African languages. This suggests that proto-Khoisan, the inferred ancestral language of all click-speakers, may have originated in East Africa, Dr. Brooks said.

The language of the first modern humans may have undergone a very early branching, Dr. Ehret said, with the Khoisan click languages on one branch and the other three language groups of Africa — Nilo-Saharan, Niger-Kordofanian and Afroasiatic — on the other branch. Clicks are difficult to pronounce fluently and with a single exception no click languages are known outside Africa.

Another finding of the Tishkoff-Ehret team is that African languages tend to be highly correlated with the genetics of their speakers, a finding that helps indicate cases of language replacement. The various Pygmy groups in Africa, the team has found, show distant genetic relationships to the San and other click-speakers, suggesting the pygmies, too, once spoke Khoisan languages but have now adopted those of their neighbors.

Another instance of a mismatch between language and genetics concerns the Luo, an ethnic group in Kenya to which President Obama’s father belonged. The Luo speak a Nilo-Saharan language and are thought of as a people of Sudanese origin, but genetically they have a heavy mixture of Bantu speakers’ genes, Dr. Tishkoff said.

Dr. Tishkoff’s team has also calculated the exit point from which a small human group — maybe a single tribal band of 150 people — left Africa some 50,000 years ago and populated the rest of the world. The region is near the midpoint of the African coast of the Red Sea.

Dr. Tishkoff and her colleagues found that the 14 ancestral African populations they detected are now highly mixed, with the exception of the Bantu speakers.

пятница, 5 июня 2009 г.

Improved Resolution Haplogroup G Phylogeny in the Y Chromosome, Revealed by a Set of Newly Characterized SNPs

Improved Resolution Haplogroup G Phylogeny in the Y Chromosome, Revealed by a Set of Newly Characterized SNPs

Sims et al

Abstract

Background: Y-SNP haplogroup G (hgG), defined by Y-SNP marker M201, is relatively uncommon in the United States general population, with only 8 additional sub-markers characterized. Many of the previously described eight sub-markers are either very rare (2–4%) or do not distinguish between major populations within this hg. In fact, prior to the current study, only 2% of our reference Caucasian population belonged to hgG and all of these individuals were in sub-haplogroup G2a, defined by P15. Additional Y-SNPs are needed in order to differentiate between individuals within this haplogroup. Principal Findings: In this work we have investigated whether we could differentiate between a population of 63 hgG individuals using previously uncharacterized Y-SNPs. We have designed assays to test these individuals using all known hgG SNPs (n = 9) and an additional 16 unreported/undefined Y-SNPS. Using a combination of DNA sequence and genetic genealogy databases, we have uncovered a total of 15 new hgG SNPs that had been previously reported but not phylogenetically characterized. Ten of the new Y-SNPs are phylogenetically equivalent to M201, one is equivalent to P15 and, interestingly, four create new, separate haplogroups. Three of the latter are more common than many of the previously defined Y-SNPs. Y-STR data from these individuals show that DYS385*12 is present in (70%) of G2a3b1-U13 individuals while only 4% of non-G2a3b1-U13 individuals posses the DYS385*12 allele.




вторник, 2 июня 2009 г.

Баварские дДНК

Kinship and Y-Chromosome Analysis of 7th Century Human Remains: Novel DNA Extraction and Typing Procedure for Ancient Material // Croat Med J. 2009 Jun;50(3):286-95

Vanek et al

http://www.cmj.hr/2009/50/3/19480023.htm

4/6 R1b1b2
2/6 G2a

Сделаны гаплотипы по 26 локусам (не полные).

Sample YSEARCH identifier

244A/244B 6QUDR
244C H78RA
244D ZYRUU
244E* H6KZ2, QCX3T
244F 2SRMA


The grave 244 makes this place one of the richest Bavarian burial sites from the late-Merowig period. The grave 244 dates to the period around 670 AD.